GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs465969 | 1 | rs4509157 | chr6:111835078 | KIAA1919 | chr6:111580482-111590259:+ | 0.44 | 5.61 | 3.39E-8 | Psoriasis |
| THCA | cis | rs4509693 | 1 | rs4509693 | chr10:102501571 | FBXW4 | chr10:103370422-103454743:- | -0.17 | -3.35 | 0.000873 | Alzheimer's disease |
| THCA | cis | rs3105593 | 1 | rs4509958 | chr15:50894175 | SPPL2A | chr15:50999739-51057910:- | 0.28 | 7.43 | 5.07E-13 | QT interval |
| THCA | cis | rs3105593 | 1 | rs4509958 | chr15:50894175 | TRPM7 | chr15:50852491-50978994:- | 0.11 | 3.47 | 0.000558 | QT interval |
| THCA | cis | rs7582720 | 1 | rs4510208 | chr2:203734866 | ALS2CR8 | chr2:203776978-203851060:+ | -0.29 | -5.93 | 5.93E-9 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs7582720 | 1 | rs4510208 | chr2:203734866 | ICA1L | chr2:203637873-203736371:- | 0.25 | 4.18 | 3.49E-5 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs4038131 | 1 | rs4510228 | chr2:17774685 | GEN1 | chr2:17935162-17966632:+ | 0.5 | 6.67 | 7.04E-11 | Psychosis and Alzheimer's disease |
| THCA | cis | rs4038131 | 1 | rs4510229 | chr2:17774701 | GEN1 | chr2:17935162-17966632:+ | 0.5 | 6.64 | 8.64E-11 | Psychosis and Alzheimer's disease |
| THCA | cis | rs2243480 | 1 | rs451396 | chr7:65484074 | CCT6P1 | chr7:65216092-65228661:+ | 0.41 | 6.48 | 2.28E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs451396 | chr7:65484074 | CRCP | chr7:65579805-65619551:+ | -0.29 | -4.42 | 1.22E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs451396 | chr7:65484074 | RABGEF1 | chr7:66093890-66276446:+ | 0.53 | 6.66 | 7.52E-11 | Diabetic kidney disease |
| THCA | cis | rs10411161 | 1 | rs4514789 | chr19:52365654 | ZNF577 | chr19:52359056-52394145:- | -0.25 | -5.97 | 4.54E-9 | Breast cancer |
| THCA | cis | rs10411161 | 1 | rs4514789 | chr19:52365654 | ZNF649 | chr19:52392489-52408247:- | -0.19 | -3.9 | 0.000112 | Breast cancer |
| THCA | cis | rs6479874 | 1 | rs4515917 | chr10:52758948 | PRKG1 | chr10:52750945-54055274:+ | -0.2 | -4.65 | 4.3E-6 | Migraine |
| THCA | cis | rs3802842 | 1 | rs4520624 | chr11:111172210 | C11orf92 | chr11:111164171-111175770:- | -0.18 | -3.84 | 0.000138 | Colorectal cancer |